By Andrew R. Collins

ISBN-10: 1617377090

ISBN-13: 9781617377099

As researchers proceed to make huge, immense development in mapping affliction genes, interesting, novel, and complicated analyses have emerged. during this ebook, scientists from around the globe, who're leaders during this box, give a contribution their mammoth event and services to supply a accomplished and interesting textual content for researchers and clinicians alike. they supply state-of-the-art research of the main updated and preeminent info to be had.

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As researchers proceed to make huge, immense growth in mapping affliction genes, interesting, novel, and complicated analyses have emerged. during this e-book, scientists from worldwide, who're leaders during this box, give a contribution their colossal event and services to supply a finished and engaging textual content for researchers and clinicians alike.

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If representative of the genome, this implies a total in the region of 100 thousand hot spots that corresponds well with the number of steps in the LDU maps (Table 2). However, because LDU maps reflect patterns of LD that are influenced by factors such as genetic drift, selection, and mutation in addition to 03_Tapper 6/6/07 2:55 PM Page 35 LD Maps and Databases 35 Fig. 4. The relationship in the human genome between linkage disequilibrium unit and linkage in chromosome arms and deciles. Fig. 5.

This might be attributed to the local effect of block structure, which can distort L (4), therefore Lp is used throughout in LDMAP. Typically there are small numbers of intervals where εidi exceeds 3, termed “holes” (6). In high-density maps holes are associated with a locally high recombination rate, and segments requiring local increases in marker density can thus be identified (17). When an estimate εi bounds at zero (consistent with “complete” LD), that estimate is fixed at zero and no further iteration takes place, with a consequent reduction in computation time.

Et al. (2002) Detecting recent positive 3. selection in the human genome from haplotype structure. Nature 419, 832–837. , et al. (2003) Linkage disequilibrium in human 4. populations. Proc. Natl. Acad. Sci. USA 100, 6069–6074. 5 Daly, M. , Rioux, J. , Schaffner, S. , Hudson, T. , and Lander, E. S. (2001) 5. High-resolution haplotype structure in the human genome. Nat. Genet. 29, 229–232. 6 Tapper, W. , Morton, N. , and Collins, A. (2003) A metric 6. linkage disequilibrium map of a human chromosome.

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Linkage Disequilibrium and Association Mapping by Andrew R. Collins


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