By Geoffrey S. Pitt

ISBN-10: 0128020024

ISBN-13: 9780128020029

ISBN-10: 0128020172

ISBN-13: 9780128020173

Ion Channels in wellbeing and fitness and Disease offers key perception to permit researchers to generate discoveries throughout ailment states. A unmarried source that integrates disparate components of biology and disorder ion channel biology, this booklet comprises cross-referencing for affliction, channels, and tissues. bargains a huge view of study of curiosity to early and skilled researchers throughout organic and biomedical research.

  • Provides an summary of primary thoughts in ion channels examine to hyperlink defects in human disease
  • Written in an obtainable demeanour, with out jargon
  • Provides a priceless, effortless cross-reference for ailments, channels, and tissues

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Sample text

2 channels trafficking to T-tubules, followed by an exploration of the critical components in the machinery. 2 Channels The first example of targeted delivery of ion channels to cardiomyocyte surface subdomains is the delivery of Cx43 connexons to the intercalated discs. 34 Through interaction with another plus-end protein, p150Glued, the EB1tipped microtubule complexes specifically with β-catenin molecules at the fascia adherens of intercalated discs. Vesicular cargo is unloaded and subsequently inserted into the plasma membrane at nearby gap junctions.

All rights reserved. 26 2. ION CHANNEL TRAFFICKING at T-tubules. The question for cardiomyocytes is how, in normal physiologic conditions, particular regions of membrane are populated with the appropriate proteins. It is critical to understand the dynamic intracellular environment that contains rapid protein movements and very frequent protein turnover. Cardiomyocytes in diseased and failing hearts are subjected to environments with less energy and more stress. In response the cells undergo not just pathologic remodeling of membrane structures and proteins, but also alterations of protein movement and turnover.

In 2011, Rhett et al. 86 Such local movements of Cx43 and other channels are highly likely and areas such as the perinexus could be transitional zones in which further posttranslational modification and clustering occur. 87,88 We speculate that membrane morphology such as location of critical curvature and inflection points may compartmentalize trafficking domains as well as support structures such as the perinexus, thereby affecting channel activity. 23 Immunocytochemistry and patch clamp data indicate that 80% of the sarcolemma LTCCs are concentrated at T-tubules.

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Ion Channels in Health and Disease by Geoffrey S. Pitt


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