By Neale Ridgway, Roger McLeod
Biochemistry of Lipids: Lipoproteins and Membranes, quantity Six, includes concise chapters that conceal a large spectrum of subject matters within the box of lipid biochemistry and telephone biology. It offers a huge bridge among broad-based biochemistry textbooks and extra technical study courses, supplying cohesive, foundational details.
It is a invaluable instrument for complicated graduate scholars and researchers who're drawn to exploring lipid biology in additional element, and contains overviews of lipid biology in either prokaryotes and eukaryotes, whereas additionally delivering basic heritage at the next descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of advanced phospholipids, sphingolipids, and their structural editions. additionally coated are sections on how bioactive lipids are curious about cellphone signaling with an emphasis on sickness implications and pathological consequences.
- Serves as a common reference publication for scientists learning lipids, lipoproteins and membranes and as a complicated and up to date textbook for academics and scholars who're accustomed to the fundamental recommendations of lipid biochemistry
- References from present literature could be integrated in every one bankruptcy to facilitate extra in-depth study
- Key ideas are supported by means of figures and types to enhance reader understanding
- Chapters offer historic standpoint and present research of every topic
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Biochemistry of Lipids: Lipoproteins and Membranes, quantity Six, comprises concise chapters that conceal a large spectrum of subject matters within the box of lipid biochemistry and mobilephone biology. It offers a huge bridge among broad-based biochemistry textbooks and extra technical learn guides, supplying cohesive, foundational info.
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Additional info for Biochemistry of Lipids, Lipoproteins and Membranes, Sixth Edition
Signal transduction cascades are organised into functional membrane microdomains that are enriched in polyisoprenoid lipids and/or CL. The insolubility of these microdomains in Triton X-100 and the presence of polyisoprenoid lipids (rather than cholesterol) suggest a similar organisation of proteins and lipid as seen in eukaryotic lipid rafts (Bramkamp and Lopez, 2015). SUMMARY AND FUTURE DIRECTIONS Biological membranes due to their lipid component are flexible self-sealing boundaries that form the permeability barrier for cells and organelles and provide the means to compartmentalise functions; at the same time they perform many other duties.
Acta 1666, 2–18. , 2013. Bacterial lipids: metabolism and membrane homeostasis. Prog. Lipid Res. 52, 249–276. , 2014. Novel methods for liposome preparation. Chem. Phys. Lipids 177, 8–18. , 2003. Cardiolipin stabilizes respiratory chain supercomplexes. J. Biol. Chem. 278, 52873–52880. , 1990. Biochemistry of endotoxins. Annu. Rev. Biochem. 59, 129–170. , 2012. Association of the chromosome replication initiator DnaA with the Escherichia coli inner membrane in vivo: quantity and mode of binding.
Lymphoblasts from patients with Barth syndrome display decreased stability of the respiratory supercomplexes, suggesting that loss of mature CL species in Barth syndrome results in an altered organisation of the respiratory chain. Reduced supercomplex formation is also seen in yeast TAZ1 gene mutants. However, yeast mutants in the deacylase that initiates CL remodelling do not display a phenotype even though their CL pool has not been remodelled. This result would suggest that the level of CL (also decreased in TAZ mutants) is more critical in regulating supercomplex formation than the degree of its remodelling.
Biochemistry of Lipids, Lipoproteins and Membranes, Sixth Edition by Neale Ridgway, Roger McLeod